ANVS401 is currently being tested in a Phase 2 clinical trial ( NCT02925650 ), called DISCOVER, in people with early stage or probable Alzheimer's disease. The. Patients treated with ANVS401 for 25 days showed statistically significant cognitive improvement as measured by the Alzheimer's Disease Assessment Scale-Cognitive Subscale 11 (ADAS-Cog11). Credit: Birth Into Being. Annovis Bio, Inc. (ANVS) Materially Misrepresented the Outcome of its ANVS401 Clinical Trials. . Dr. Maria L. Maccecchini, CEO of Annovis Bio, explained: "We previously reported that ANVS401 significantly increased speed, coordination and motor function in PD patients in this trial. The trial is currently recruiting and information about eligibility and locations is available here. A total of 40 participants were randomly assigned to receive ANVS401 at daily doses of 5, 10, 20, or 40 milligrams. Period 2 consists of an at home dosing period of 25±2 days, with daily administration of 5, 10, 20, or 40mg of Posiphen. The two-part study, which received IRB approval in July 2020, is designed to treat a combined total of 28 AD and PD patients for four weeks with Annovis' lead compound, ANVS401. The launch of the Phase 2a trial ( NCT04524351) marks the second such study investigating ANVS401, and the first to enroll patients with Parkinson's disease. ANVS401 shows improvements in Phase 2a clinical trials: - Cognition in AD patients - Motor function in PD patients - WAIS coding in AD and PD patients This is the first double-blind, placebo-controlled study that shows improvements in AD patients as measured by ADAS-Cog and in PD patients as measured UPDRS Annovis Bio Completes Dosing of Parkinson's Disease Patients with ANVS401 in Phase 2a Clinical Trial Published: Aug 11, 2021 0 additional patients completed treatment On track to disclose final safety and efficacy data in early Fall Toxic cascade markers expected to be disclosed in two to three months The trial ( NCT04524351) will recruit up to 68 participants at 15 sites scattered across the U.S. Annovis Bio, Inc. (ANVS) is Accused of Materially Misrepresented the Outcome of its ANVS401 Clinical Trials. July 30, 2021. The company is now planning a Phase 2a clinical trial to assess ANVS401 in up to 50 Parkinson's patients. During the trial, researchers were evaluated ANVS401, an investigational compound for patients with Alzheimer's disease (AD), Alzheimer's disease and dementia in Down syndrome (AD-DS), and Parkinson's disease (PD). BERWYN, PA., October 5, 2021 --Annovis Bio, Inc. (NYSE American: ANVS) ("Annovis" or the "Company"), a clinical-stage drug platform company addressing Alzheimer's disease (AD), Parkinson's disease (PD) and other neurodegenerative diseases, today announced results from the completed dose response Phase 2 clinical trial of ANVS401 in 54 PD . and include, without limitation, statements regarding the timing, effectiveness, and anticipated results of ANVS401 clinical trials. Current Report Filing (8-k) Edgar (US Regulatory) - 12/17/2021 4:31:27 PM Alzamend says Alzheimer's drug was equivalent to current therapy in early study Seeking Alpha - 12/17/2021 10:23:36 AM: Alzamend Neuro Announces Positive Topline Data from Phase 1 First-in-Human Clinical Trial for AL001 Treatment of Dementia Related to Alzheimer's Business Wire - 12/17/2021 9:00:00 AM The clinical trial is expected to conclude in the spring of 2021 with interim data expected later in 2020. PNT article: First Patients Dosed in Clinical Trial Investigating ANVS401 as Treatment for Parkinson's and Alzheimer's Link to article about possible upcoming Phase III clinical trial for Parkinson's Disease sponsored by Pennsylvania based biotech - Annovis. Annovis Bio is conducting an ongoing Phase 2a clinical trial in AD and PD patients to compare, in both patient populations, how nerve cells die by measuring all the steps in the toxic cascade . ANVS401 is a small molecule that targets α-synuclein and is administrated orally. The first was a single ascending dose (SAD) study in 72 healthy volunteers. ANVS401 is orally available, well behaved, and well qualified as a candidate to treat neurodegeneration (AD,AD-DS and PD). (NYSE American: ANVS) ("Annovis" or the "Company"), a clinical-stage drug platform company addressing Alzheimer's disease (AD), Parkinson's disease (PD) and other neurodegenerative diseases, today announced results from the completed dose response Phase 2 clinical trial of ANVS401 in 54 PD patients, which found that once-daily ANVS401 was . Clinical-stage neurodegenerative disease-focused platform company Annovis Bio Inc. (ANVS:NYSE American), which is engaged in developing medicines to treat Alzheimer's disease (AD) and Parkinson's disease (PD), announced that "it is pleased by the positive interim results released on July 28 from Phase 2 clinical trials of its lead compound, ANVS401 (Posiphen)." ANVS401 has been found to be well-tolerated and safe with no adverse effects related to treatment observed. Annovis Bio (NYSE: ANVS) gains 12% premarket after announcing results from the completed dose response Phase 2 clinical trial of ANVS401 in 54 Parkinson's disease (PD) patients, which found that . By preventing the overexpression of these neurotoxic proteins, ANVS401 reverses the downstream toxic cascade that leads to neurodegeneration. Data from the Phase 2a clinical trial presented today at CTAD showed that treatment with ANVS401 reduced neurotoxic proteins in both AD and PD patients (Figure 1). Participants will be split into four groups and given either ANVS401 at 60 mg, 120 mg, or 180 mg, or a placebo, as a capsule three times a day for 23 to 25 days. Further, ANVS401 decreased. effectiveness, and anticipated results of ANVS401 clinical trials. Data from the Phase 2a clinical trial presented today at CTAD showed that treatment with ANVS401 reduced neurotoxic proteins in both AD and PD patients (Figure 1). The oral presentation will elaborate on new biomarker data from the initial Phase 2 clinical trial, as well as expanded safety information from the full range . The clinical trial was designed to test the effects of ANVS401, the Company's lead compound, on neurotoxic proteins in human spinal fluid by stable isotope labeling kinetics (SILK) for the treatment of Alzheimer's disease. Data from the Phase 2a clinical trial presented today at CTAD showed that treatment with ANVS401 reduced neurotoxic proteins in both AD and PD patients (Figure 1). When compared to the placebo group, statistically significant improvements in WAIS coding scores were observed in PD patients taking ANVS401 5mg, 20mg and 80mg once daily, highlighting increased motor-dexterity, as well as speed and . Data from the Phase 2a clinical trial presented today at CTAD showed that treatment with ANVS401 reduced neurotoxic proteins in both AD and PD patients (Figure 1). effectiveness and anticipated results of ANVS401 clinical trials . In an interim analysis of an ongoing Phase 2a clinical trial in AD patients, the Data Safety Monitoring Board recommended the trial continue without modification. The trial's primary goals are to . Berwyn, Pennsylvania--(Newsfile Corp. - November 9, 2021) - Annovis Bio, Inc. (NYSE American: ANVS) ("Annovis" or the "Company"), a clinical-stage drug platform company addressing Alzheimer's disease (AD), Parkinson's disease (PD), and other neurodegenerative diseases, today announced that Vice President . Its lead compound is ANVS401 (Posiphen), which purportedly inhibited the synthesis of neurotoxic proteins that are the main c. According to a class action complaint filed on behalf of purchasers of Annovis between . Each trial will likely recruit approximately 450 patients, split evenly among three groups: placebo, 10mg, and 20mg a day of ANVS401, Maccecchini explains. The first was a single ascending dose (SAD) study in 72 healthy volunteers. The DSMB reviewed safety data, enrollment, participant status, demographic data, and vital signs of the 11 patients currently . ANVS401 is being developed to treat Alzheimer's, Parkinson's disease and Alzheimer's in Down Syndrome. ANVS401 is orally available, well behaved and well qualified as a candidate to treat neurodegeneration (AD,AD-DS and PD). Annovis' lead compound, ANVS401, is an oral translational inhibitor of neurotoxic aggregating proteins (TINAP) currently being developed for AD, AD in Down Syndrome (AD-DS), and PD. Annovis reported its first statistically significant interim data from these trials in March 2021, demonstrating ANVS401 improved patients' speed and coordination scores in key Parkinson's . 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